An Oxidative Stress Index-Based Score for Prognostic Prediction in Colorectal Cancer Patients Undergoing Surgery

Table 3

Univariate and multivariate analyses of factors associated with OS.

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P
Age (years)
≥60	1.14 (0.85-1.54)	0.378
<60	Ref.	-
Sex, male	1.18 (0.87-1.60)	0.296
Primary site
Left colon	1.56 (1.11-2.20)	0.011	1.29 (0.90-1.84)	0.169
Right colon	1.73 (1.18-2.54)	0.005	1.24 (0.83-1.86)	0.302
Rectum	Ref.	-	Ref.	-
Family history of cancer	1.03 (0.63-1.71)	0.901
Histological grade
Well differentiated	Ref.	-
Moderately differentiated	1.23 (0.63-2.42)	0.547
Poorly differentiated	1.44 (0.69-3.03)	0.336
Tumor size
<2 cm	0.60 (0.28-1.29)	0.190	0.82 (0.36-1.86)	0.628
2-5 cm	0.61 (0.45-0.83)	0.002	0.79 (0.58-1.09)	0.147
≥5 cm	Ref.	-	Ref.	-
Lymphovascular invasion
Yes	1.01 (0.67-1.50)	0.983
No	Ref.	-
Circumferential resection margin
Yes	0.62 (0.09-4.41)	0.630
No	Ref.	-
T stage
T1	Ref.	-	Ref.	-
T2	0.83 (0.31-2.22)	0.714	0.84 (0.30-2.37)	0.748
T3	1.70 (0.74-3.91)	0.212	1.30 (0.51-3.29)	0.583
T4	5.38 (2.35-12.32)	<0.001	2.79 (1.10-7.09)	0.031
N stage
N0	Ref.	-	Ref.	-
N1	0.56 (0.28-1.15)	0.114	0.65 (0.31-1.35)	0.245
N2	1.51 (0.74-3.05)	0.256	1.29 (0.59-2.83)	0.530
N3	2.86 (1.42-5.76)	0.003	1.82 (0.84-3.96)	0.132
TNM stage
Stage I	Ref.	-	Ref.	-
Stage II	1.77 (0.78-4.02)	0.170	0.81 (0.32-2.08)	0.668
Stage III	4.07 (1.87-8.82)	<0.001	1.07 (0.42-2.71)	0.892
Stage IV	10.47 (4.78-22.93)	<0.001	3.44 (1.37-8.63)	0.009
Adjuvant chemotherapy
Yes	0.66 (0.49-0.90)	0.008	0.72 (0.52-0.98)	0.045
No	Ref.	-	Ref.	-
Radiotherapy
Yes	0.98 (0.48-1.98)	0.945
No	Ref.	-
CIOSS
Low	Ref.	-	Ref.	-
Intermediate	3.08 (2.12-4.48)	<0.001	2.93 (1.99-4.32)	<0.001
High	5.09 (3.40-7.64)	<0.001	4.33 (2.80-6.68)	<0.001