An Oxidative Stress Index-Based Score for Prognostic Prediction in Colorectal Cancer Patients Undergoing Surgery

Table 4

Univariate and multivariate analyses of factors associated with DFS.

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P
Age (years)
≥60	1.13 (0.82-1.55)	0.457
<60	Ref.	-
Sex, male	1.02 (0.74-1.41)	0.886
Primary site
Left colon	1.40 (0.98-2.02)	0.068	1.15 (0.79-1.67)	0.481
Right colon	1.52 (1.01-2.29)	0.048	1.26 (0.82-1.93)	0.303
Rectum	Ref.	-
Family history of cancer	1.26 (0.70-2.26)	0.450
Histological grade
Well differentiated	Ref.	-
Moderately differentiated	1.31 (0.81-2.12)	0.279
Poorly differentiated	1.50 (0.73-3.09)	0.272
Tumor size
<2 cm	0.71 (0.31-1.64)	0.421
2-5 cm	0.88 (0.63-1.23)	0.453
≥5 cm	Ref.	-
Lymphovascular invasion
Yes	0.96 (0.62-1.48)	0.845
No	Ref.	-
Circumferential resection margin
Yes	1.49 (0.37-6.03)	0.573
No	Ref.	-
T stage
T1	Ref.	-	Ref.	-
T2	2.21 (0.49-9.96)	0.303	2.93 (0.63-13.55)	0.170
T3	4.39 (1.07-17.92)	0.040	3.71 (0.88-15.73)	0.075
T4	13.23 (3.25-53.88)	<0.001	6.80 (1.60-28.87)	0.009
N stage
N0	Ref.	-	Ref.	-
N1	0.83 (0.35-1.93)	0.659	1.02 (0.43-2.43)	0.958
N2	1.87 (0.80-4.38)	0.152	1.30 (0.53-3.19)	0.570
N3	4.00 (1.71-9.23)	0.001	1.88 (0.78-4.51)	0.160
TNM stage
Stage I	Ref.	-	Ref.	-
Stage II	2.63 (0.78-8.81)	0.118	1.38 (0.37-5.16)	0.634
Stage III	5.64 (1.76-18.09)	0.004	2.24 (0.61-8.18)	0.223
Stage IV	33.45 (10.56-105.93)	<0.001	13.09 (3.63-47.19)	<0.001
Adjuvant chemotherapy
Yes	0.82 (0.68-1.17)	0.328
No	Ref.	-
Radiotherapy
Yes	0.51 (0.29-0.91)	0.022	0.92 (0.51-1.67)	0.794
No	Ref.	-	Ref.	-
CIOSS
Low	Ref.	-	Ref.	-
Intermediate	2.17 (1.49-3.16)	<0.001	1.88 (1.29-2.76)	0.001
High	3.09 (2.02-4.71)	<0.001	3.02 (1.96-4.64)	<0.001