Cyclic Mechanical Stretch Ameliorates the Degeneration of Nucleus Pulposus Cells through Promoting the ITGA2/PI3K/AKT Signaling Pathway

Figure 5

Differential mRNA expression between the tensile stress and control groups. (a) Scatter plot showing the differential expression of mRNAs between the tensile stress and control groups. Red and green plots represent up- and downregulated genes, respectively. (b) The volcano plot showing mRNAs with differential expression between the two groups. Red and blue plots represent up- and downregulated genes, respectively. (c) Significance enrichment analysis of Gene Ontology (GO) annotation results. (d) A gene set enrichment analysis of all the differentially expressed genes showing the significantly enriched pathways based on the KEGG database. BP: biological process; MF: molecular function; CC: cellular component.

(a)

(b)

(c)

(d)