Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties

Figure 1

CAT attenuated cisplatin-induced nephrotoxicity (in vivo). Changes in kidney weight/body weight (a), serum KIM-1 (b), serum BUN (c), serum CRE (d), TUNEL staining (e), kidney tissue SOD (f), MDA (g), GSH (h), serum TNF-α (i), serum IL-6 (j), and serum IL1-β (k) after coadministration of CAT. Data were analyzed by one-way ANOVA and unpaired -tests and are presented as . ^## and ^###vs. the control group; , , and vs. the model group; ns: not significant (vs. the control group) ().

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