Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties

Figure 3

CAT attenuated cisplatin-induced damage by inhibiting apoptosis in vitro. Cell viability after treatment with various concentrations of CAT (a), cisplatin (b), and coadministration of CAT and cisplatin (c). Changes in the BAX/Bcl-2 ratio (d), TUNEL staining (e), and flow cytometry (f) after cotreatment of CAT and cisplatin. Data were analyzed by one-way ANOVA and unpaired -tests and are presented as . ^## and ^###vs. the control group; , , and vs. the cisplatin group; ns: not significant ( vs. the control group) ().

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