Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties

Figure 4

CAT activated AMPK and alleviated cisplatin-induced mitochondrial dysfunction by inhibiting ROS production in vitro. Changes in cellular ATP (a), cell IL-6 (b), cell TNF-α (c), cell IL1-β (d), cellular ROS (e), mitochondrial membrane potential (f), AMPK expression (g), LC-3 expression (h), and mitophagy activity (i) after cotreatment of CAT and cisplatin. Data were analyzed by one-way ANOVA and unpaired -tests and are presented as . ^## and ^### vs. the control group; and vs. the cisplatin group; ns: not significant (vs. the control group) ().

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