Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties

Table 1

IC₅₀ values and reversal effect of CAT on cisplatin in A549, A549/PTX, and A549/DDP cells.

Cell lines	IC50^a (μM)		Resistance Index^b	Reversal Index^c
	Cisplatin	Cisplatin+CAT (10 μM)
A549			—	1
A549/PTX		^##	4.14	2.8
A549/DDP		^##	8.10	4.15

^aIC₅₀ values represent the of three independent experiments. ^bResistance Index was calculated by dividing the IC₅₀ values of the cisplatin treatment in A549/PTX and A549/DDP cells by that of A549 cells. ^cReversal Index was calculated by dividing the IC₅₀ values of the cisplatin treatment by that of the combined cisplatin with CAT treatment. ^##vs. cisplatin group.