Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are Expressed in Both Testicular and Systemic DLBCL and Correlate with Clinical Disease Presentation

Table 1

Demographics of 28 males with systemic diffuse large B-cell lymphoma (DLBCL) and 21 testicular DLBCL patients. The mean age of all patients was 65.0, range 26–90. Correlation between systemic DLBCL and testicular DLBCL was calculated using Fisher’s exact test for B-symptoms, age, LD levels, WHO, extranodal effusion, and IPI, whereas correlation with stage was calculated with Pearson chi-square. IPI: International Prognostic Index; LD: lactate dehydrogenase; NA: not available.

	Systemic DLBCL () (%)	Testis DLBCL () (%)	value
B-symptoms			0.362
None	12 (42.9)	15 (71.4)
Yes	14 (50.0)	5 (23.8)
NA	2 (7.1)	1 (4.8)
Age			0.001
<60 years	15 (53.6)	1 (4.8)
≥60 years	13 (46.4)	20 (95.2)
LD levels			0.320
Normal	10 (35.7)	10 (47.6)
Elevated	16 (57.2)	6 (28.6)
NA	2 (7.1)	5 (23.8)
Stage			< 0.001
I–II	9 (32.1)	18 (85.7)
III–IV	19 (67.9)	3 (14.3)
WHO performance status			0.727
0–1	19 (67.9)	18 (85.7)
>1	7 (25.0)	3 (14.3)
NA	2 (7.1)
Extranodal effusion			0.467
0–1	22 (78.6)	18 (85.7)
>1	6 (21.4)	3 (14.3)
IPI			0.111
0–2	14 (50.0)	17 (81.0)
3–5	12 (42.9)	4 (19.0)
NA	2 (7.1)