TNF-<i>α</i> Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway

<div>Intestinal ischemia-reperfusion- (IIR-) induced acute lung injury. A mouse model of IIR injury was constructed, and the pathomorphological changes of the small intestinal tissue (a) and lung tissue (b) were detected using hematoxylin and eosin (HE) staining. The extent of lung injury was assessed by Koksel’s scoring method (c), and the water content of lung tissue was also determined (d). Changes in the expression of the polymorphonuclear neutrophil (PMN) marker MPO in lung tissue were detected using ELISA. 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Sham: sham-operated group; IIR: intestinal ischemia-reperfusion model group.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: TNF-<i>α</i> Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway 

Figure 1 | TNF-α Induces Neutrophil Apoptosis Delay and Promotes Intestinal Ischemia-Reperfusion-Induced Lung Injury through Activating JNK/FoxO3a Pathway 