Hormone Replacement Therapy and Aging: A Potential Therapeutic Approach for Age-Related Oxidative Stress and Cardiac Remodeling

Figure 5

(a) The effects of the aging process and E₂/RAL treatment on cardiac MMP-2 activity (64 kDa MMP-2, expressed as ). Result shown as . –10. : statistical significance relative to the control group. ^#: statistical significance relative to the aging group. E₂: estrogen; RAL: raloxifene. (b) The effects of the aging process and E₂/RAL treatment on cardiac TIMP-2 concentration (TIMP-2, expressed as ng/mg protein). Result shown as . –9. : statistical significance relative to the control group. ^#: statistical significance relative to the aging group. E₂: estrogen; RAL: raloxifene.

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