Research Article
Transcriptional Profiling of Exosomes Derived from Staphylococcus aureus-Infected Bovine Mammary Epithelial Cell Line MAC-T by RNA-Seq Analysis
Table 5
Differentially expressed genes in exosomes and KEGG enrichment.
| | Gene | log2 (Fold_change) | value | KEGG pathway |
| | Up | ALG10 | 5.91 | 3.24-04 | N-Glycan biosynthesis; metabolic pathways | | UBE2G2 | 5.64 | 2.95-05 | Ubiquitin-mediated proteolysis; protein processing in endoplasmic reticulum | | ZMAT3 | 3.49 | 1.30-04 | p53 signaling pathway | | CCNT2 | 3.04 | 1.72-05 | Transcriptional misregulation in cancer | | C1D | 2.28 | 5.08-04 | RNA degradation | | ARHGAP5 | 2.20 | 1.67-04 | Leukocyte transendothelial migration; focal adhesion | | TAOK1 | 1.92 | 3.38-04 | MAPK signaling pathway | | GALNT1 | 1.92 | 6.46-05 | Mucin type O-glycan biosynthesis; metabolic pathways | | CD2AP | 1.55 | 2.41-04 | Bacterial invasion of epithelial cells | | HNRNPM | 1.40 | 3.13-04 | Spliceosome |
| | Down | CSF1 | -8.66 | 7.76-07 | Ras signaling pathway; Rap1 signaling pathway; TNF signaling pathway; PI3K-Akt signaling pathway; cytokine-cytokine receptor interaction | | DSG1 | -8.33 | 6.55-06 | Staphylococcus aureus infection | | NTNG2 | -7.80 | 1.97-04 | Cell adhesion molecules; axon guidance | | NR1H3 | -7.06 | 1.02-04 | PPAR signaling pathway; insulin resistance; hepatitis C; nonalcoholic fatty liver disease | | CYP1A2 | -6.63 | 5.54-04 | Linoleic acid metabolism; tryptophan metabolism; retinol metabolism; steroid hormone biosynthesis; drug metabolism- cytochrome P450; metabolic pathways; chemical carcinogenesis | | MECOM | -5.36 | 1.44-04 | MAPK signaling pathway; chronic myeloid leukemia; pathways in cancer | | RELN | -4.79 | 1.39-04 | ECM-receptor interaction; PI3K-Akt signaling pathway; focal adhesion | | PLA2G4B | -4.23 | 3.12-04 | Linoleic acid metabolism; Glutamatergic synapse; Ras signaling pathway; Arachidonic acid metabolism; alpha-Linolenic acid metabolism; ether lipid metabolism; VEGF signaling pathway; fc epsilon RI signaling pathway; MAPK signaling pathway; GnRH signaling pathway; inflammatory mediator regulation of TRP channels; phospholipase D signaling pathway; oxytocin signaling pathway | | GRIN2A | -3.58 | 5.94-04 | cAMP signaling pathway; glutamatergic synapse; Ras signaling pathway; calcium signaling pathway; Rap1 signaling pathway | | PRKDC | -3.03 | 1.28-04 | Cell cycle; nonhomologous end-joining |
|
|
