RETRACTED: Resveratrol Derivative, Trans-3, 5, 4-Trimethoxystilbene Sensitizes Osteosarcoma Cells to Apoptosis via ROS-Induced Caspases Activation

Figure 7

Treatment with TMS overcomes TRAIL resistance and promotes apoptotic cell death of MG-63 cell via activating p53 and PUMA. (a) Wild-type MG-63 cell, (b) p53−/− MG-63 cell or (c) wild-type MG-63 cell, and (d) PUMA −/− MG-63 cell were pretreated by TRAIL (50 ng/mL) and TMS (2.5 μm) for 10 h. Equal volume of PBS+0.1% DMSO 0.01% + BSA was used as vehicle control. Cell survival was examined as indicated in the experimental method section. Immunoblotting was used to detect the expression of cleaved PARP1, p53, or PUMA. .

(a)

(b)

(c)

(d)