RETRACTED: Resveratrol Derivative, Trans-3, 5, 4-Trimethoxystilbene Sensitizes Osteosarcoma Cells to Apoptosis via ROS-Induced Caspases Activation

Figure 9

Cotreatment with TMS and TRAIL suppresses the proliferation of cancer cells in nude mice transplanted with osteosarcoma. (a) Sizes of osteosarcoma tumors in nude mice subjected to different treatment regimens. (b) Tumor volume and weight were significantly decreased in TRAIL (100 ng/g) + TMS (1 μg/g)-treated group compared with those of the other groups. No obvious changes in body weight were noted among mice subjected to different treatment regimens. ; versus control. (c) The expression of Bax, PUMA, and P53 was evaluated using immunohistochemistry (IHC). The scored IHC results were analyzed by multiplying the percentages of positive cells by the intensity score obtained using confocal microscopy. Signal intensity was analyzed and scored by two independent pathologists. The score of 0 indicates lack of staining, 1 indicates mild staining, and 2 indicates obvious staining. Osteosarcoma cells in five separate areas were chosen at random and analyzed according to the percentages of positively labeled cells ().

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