Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK

Figure 1

Impacts of H₂O₂ and farrerol on ARPE-19 cells’ viability. (a) Chemical structure of farrerol (Farr) (MW = molecular weight). ARPE-19 cells were dealt with different doses of H₂O₂ (75-1200 μM) (b) or farrerol (5–80 mg/L) (c) for 24 h. And then, the CCK-8 was utilized to calculate the cell viability. (d) Cells were pretreated with farrerol at concentrations of 5, 10, and 20 mg/L for 1 h followed by 300 μM H₂O₂ stimulation for 24 h, and then, CCK-8 was utilized to evaluate cell survival. Similar results were illustrated from three independent experiments. and compared with the control group; ^# and ^## compared with the H₂O₂ group.

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