Activation of Nrf2 by miR-152 Inhibits Doxorubicin-Induced Cardiotoxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Figure 2

miR-152 overexpression improved cardiac function in mice with DOX treatment. (a) The miR-152 expression after AAV injection (). (b) Body weight of four groups (). (c) Statistical results of the heart weight (HW)/tibia length (TL) (). (d–f) The level of CK, LDH, and cTnI in DOX-treated mice (). (g–i) The alteration in EF, +dP/dt, and -dP/dt in mice (). (j, k) Cardiac output and Tau_Weiss in mice (). (l) Heart rate (). Values represent the . versus NS+miR-scramble; ^# versus DOX+miR-scramble.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)