Activation of Nrf2 by miR-152 Inhibits Doxorubicin-Induced Cardiotoxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Figure 4

miR-152 reduced oxidative stress in DOX-treated mice. (a, b) The level of myocardial 3-NT and 4-HNE in the hearts (). (c, d) The levels of cardiac MDA and GSH/GSSG (). (e) Total SOD activity (). (f) The levels of Nrf2-regulated genes in the hearts (). (g) Protein expression of nuclear Nrf2 (). (h) Nrf2 activity assay (). (i) TUNEL staining (). (j, k) The protein expression of Bax and cleaved-caspase3 in the hearts (). Values represent the . versus NS+miR-scramble, versus DOX+miR-scramble.

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