Activation of Nrf2 by miR-152 Inhibits Doxorubicin-Induced Cardiotoxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Figure 6

miR-152 targeted Keap1 and activated Nrf2. (a) Luciferase assay (). (b) Keap1 mRNA level (). (c) The protein expression of Nrf2 and Keap1 (). (d) Nrf2 mRNA level (). (e) The levels of Nrf2-regulated genes (). (f) The protein expression of Nrf2 (). (g, h) TNF-α mRNA level and NF-κB activity in cardiomyocytes (). (i, j) ROS and MDA production (). (k) Cell viability (). Values represent the . versus the matched control.

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