Effect of Vitamin D Status on Vascular Function of the Aorta in a Rat Model of PCOS

Figure 1

(a) Relative contractile ability of the aorta in female rats after induced by cumulative concentrations of NE. Contraction was calculated as the percentage of maximal contraction reached after a previous 3-minute K⁺ treatment (124 mmol/L). There was no difference in the developed vasoconstriction among treatment groups regardless of norepinephrine concentration. in each group. Data are presented as . (b) Acetylcholine-mediated vasorelaxation. Dilation was compared to precontraction induced by norepinephrine. Significantly reduced relaxation was measured in VDD groups, starting at 10^-7 ACh concentration, remaining significant in growing concentrations. in each group. Two-way ANOVA, Tukey’s post hoc test. bbb: T-D- vs. T-D+ , b: T-D- vs. T-D+ , ddd: T-D- vs. T + D+ , dd: T-D- vs. T + D+ , d: T-D- vs. T + D+ , ee: T + D- vs. T + D+ . Data are presented as . (c) Insulin-dependent vasodilation. Relaxation was calculated in comparison to precontraction induced by M NE administration. Vitamin D deficient groups had compromised insulin-dependent vasodilatation in 120 mikroU/ml insulin concentration and above. in each group.Two-way ANOVA, Tukey’s post hoc test. bbb: T-D- vs. T-D+ , bb: T-D- vs. T-D+ , ccc: T + D- vs. T-D+ , ddd: T-D- vs. T + D+ , dd: T-D- vs. T + D+ , d: T-D- vs. T + D+ , eee: T + D- vs. T + D+ , ee: T + D- vs. T + D+ . Data are presented as .

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