Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway

Figure 1

Synthesis of BOX A and BOX B and their permeability though the blood-brain barrier. (a) The chemical synthesis scheme of BOX A and BOX B. (b) Brain concentration (ng/g) and plasma concentration (ng/mL) of male ICR mice receiving in vein injection with a single dose of 12 mg/kg BOX A or BOX B and 30 min later, then collected samples for measurement. (c) Ratio of brain concentration to the plasm concentration (B/P ratio) of BOX A and BOX B in ICR mice. (b and c) Data represent (), unpaired Student’s -test, , and .