Research Article

Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway

Figure 4

BOX A and BOX B decrease the mitochondrial membrane potential in neurons. (a) Representative FACS analysis of the mitochondrial membrane potential in SH-SY5Y cells using JC-1 staining (); the fraction of monomer is indicative of depolarized mitochondria. The concentrations of BOXes are indicated for 48 h incubation. (b) Normalized monomer (%) as shown in (a). Data represented as (), ANOVA, and Bonferroni post hoc test. vs. vehicle (0.1% DMSO).
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