Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway

Figure 7

Proposed model of BOX A or BOX B inducing oxidative stress and activation of antioxidant response in neurons. BOX A or BOX B induced oxidative stress and enhanced the nuclear accumulation of Nrf2 to activate the transcription of target genes harboring antioxidant response element (ARE).