Research Article

Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy

Table 7

Clusters of MBHD-VD PPI network.

ClusterScoreNodesEdgesTargets and genes

152.567681761PIK3CD, PIK3CG, PIK3CA, IL1B, PLA2G1B, ERBB2, NGF, BDNF, MAPK14, MAPK9, CASP3, CAT, CSF2, GFAP, CALM1, TIMP1, EGFR, ESR1, CALM3, NOS3, STAT3, VEGFA, TNF, HSP90AA1, CALM2, ACE, IGF1, APOE, APP, TLR9, SERPINE1, ICAM1, MMP9, FGF2, NR3C1, TGFB1, REL, RELA, GAPDH, CREB1, JUN, AKT1, CASP9, BCL2, BCL2L1, PTGS2, MAPK8, MAPK3, CYCS, AR, KDR, FLT1, F2, CXCR4, FAS, IL6, NOS2, MAPK1, PLG, CASP8, PPARG, MT3, SRC, CD40, TF, STAT1, TNFRSF1A, MMP2
2829112ESR2, PRKCG, GRM5, FPR2, PLCB1, MAPT, GSK3A, PTAFR, FGFR1, SREBF1, GRM1, SOD1, LRRK2, CRH, FLT4, AVP, ITIH4, CHRM1, CDK5, NPY, HCK, HTR2A, ADRA1B, ADRA1A, S100B, ADRA1D, CHRM3, LGALS3, CHRM5
362057CETP, APLP2, SLC6A3, IDE, OGT, SREBF2, BACE1, MBNL1, ECE1, AATF, APLP1, ABCA1, CSTB, NR1H3, NR1H2, HMGCR, TTR, LRP1, PTPRF, PRNP
45.7692775FGF1, AGT, ERBB3, JUND, AKT2, NOS1, IL5, MET, MBP, LDLR, SYK, GSK3B, MCL1, PLAU, MMP3, MMP1, BCR, LYN, LCK, FYN, ADIPOQ, CDK4, CDK1, VWF, AGTR1, MMP13, HMOX1
55.6672568CHRM4, PRKCB, CHRM2, ERN1, ADORA1, SYP, SNCA, ACTC1, GRIN2B, CNR2, CNR1, HTR1B, LPL, HTR1A, APOA1, MAP2, PPP3CA, BLK, HSP90B1, GAL, FGR, F7, YES1, APOB, PRKCD
64.8612ALDH1A2, CRYZ, ALDH2, ALDH1A3, CBR3, CBR1
74712VIP, SLC18A3, UBQLN2, ACHE, DNM1, PICALM, UBB
8458AKR1A1, AKR1B10, ALDH1L1, AKR1B15, ALDH1L2
93.667711AOX1, MAOA, ALDH1B1, ALDH1A1, RDH8, AKR1B1, HSD11B1L
103.51321TOP2A, A2M, SERPINA3, FGFR3, DLG4, HSP90AB1, CLU, GRIN2A, PSEN1, GRIN1, APOH, ELANE, CTSB
113.268PRKCA, MAPK11, ADAM17, ERBB4, GDNF, NGFR
12333GLI3, GLI2, GLI1
13356DLST, MT-CO1, DHFRL1, SDHB, DHFR
14333LBR, CYP46A1, CYP51A1