Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction

<div>Screening and identification of circRNA1615 targeting LRP6 in the process of MI. (a) To construct a circRNA-miRNA-LRP6 regulatory network through the CLIP database. (b and c) Based on the analysis of LRP6 regulatory network. Evaluation of the binding ability of mmu-miR-466c-5p, mmu-miR-466o-5p, mmu-miR-679-5p miRNA, and the representative of the expression of miR-152-3p in the GEO database data (GSE90123) and our experiment. (d) The expression of five circRNAs targeting miR-152-3p in mouse myocardial tissue. (e) Effect of the expression of circRNA1615 after hypoxia. Pooled data: biological replication indicated five mice of each group in (b–e). 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(f and g) Representative of circRNA1615 derived from Copb1 gene.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction 