Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction

<div>circRNA1615 targets LRP6 through sponge miR-152-3p. (a) Luciferase assay for the ability of circRNA1615 binding to miR-152-3p. (b) circRNA1615 precipitated with miR-152-3p and AGO2 antibodies in an RIP experiment. (c) The expression of miR-152-3p in cardiomyocytes after overexpression or knocking down of circRNA1615. (d) Analysis of the binding sites of miR-152-3p and LRP6. (e) The presented expression of LRP6 after overexpression or knocking down of miR-152-3p. Left: pooled data. Right: the presented typical blots were representative. Pooled data (a–e): biological replication indicated five mice in each group. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction 