miR-4454 Promotes Hepatic Carcinoma Progression by Targeting Vps4A and Rab27A

Figure 5

Validation of miRNAs with the highest differential expressions. After HepG2 cells were treated with heat shock, TGF-β1, doxorubicin, acidic, and H/R, exosomes were extracted from HepG2 cell culture supernatants. (a) miRNA expression distributions were displayed using heatmap between the heat shock, TGF-β1, doxorubicin, acidic, or H/R treatment groups and control group. (b) The heatmap showed the expressions of miRNAs among the heat shock, TGF-β1, doxorubicin, acidic, or H/R treatment groups and control group. (c) The top six upregulated miRNAs and the top six downregulated miRNAs were verified by qRT-PCR assay in each exosome group.

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