1-Nitropyrene Induced Reactive Oxygen Species–Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation

<div>1-NP induced the activation of AMPK/Nrf-2/HO-1 pathway in RAW264.7 macrophages. AMPK phosphorylation (a), Nrf-2 expression (b), and HO-1 expression (c) were measured by colormetric assay kit after cells were treated with 1-NP. The change in fold of AMPK phosphorylation, Nrf-2 expression, and HO-1 expression between the treated and control groups was calculated. 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Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: 1-Nitropyrene Induced Reactive Oxygen Species–Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation 

Figure 8 | 1-Nitropyrene Induced Reactive Oxygen Species–Mediated Apoptosis in Macrophages through AIF Nuclear Translocation and AMPK/Nrf-2/HO-1 Pathway Activation 