lncRNA NONHSAT069381 and NONHSAT140844 Increase in Aging Human Blood, Regulating Cardiomyocyte Apoptosis

Figure 1

The RNA expression profiles and bioinformatics analysis in older adult and young human blood samples. Heatmaps of total (a) lncRNA and (b) miRNA from older adult and young human blood. Heatmaps demonstrate (c) lncRNA (NONHSAT069381 and NONHSAT140844) and (d) miRNA (hsa-miR-124-5p and hsa-miR-6507-5p) profiles that differentiate older adult and young human blood (each sample was assayed in triplicate). (e) NONHSAT069381, (f) NONHSAT140844, (g) hsa-miR-124-5p, and (h) hsa-miR-6507-5p expression is different in older adult and young human blood. (i) Relationships between different lncRNAs, miRNAs, and mRNAs. (j) Magnified (Figure 2(i)) portion. (k) Different lncRNA and miRNA expressions confirmed by RT-PCR. Diamond nodes represent mRNA, box nodes represent lncRNA, and triangle nodes represent miRNA. versus the young group.

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