Bortezomib Rescues Ovariectomy-Induced Bone Loss via SMURF-Mediated Ubiquitination Pathway

Figure 7

In vivo administration of bortezomib alleviates OVX-induced bone loss in mice. Bortezomib exerts a dual effect on promoting osteogenesis and suppressing osteoclastogenesis in vitro. Mechanically, bortezomib-mediated antiosteoporotic effect depends on the SMURF-related ubiquitination pathway.