Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2

<div>Effect of AST IV on the NLRP3/Caspase-1/GSDMD pathway via Nrf2 in MCAO/R rats. (a) Western blot assay showing the expression levels of NLRP3, Caspase-1, IL-1<i>β</i>, GSDMD, and GSDMD-N. (b)–(f) Quantitative analysis of the expression levels of NLRP3, Caspase-1, IL-1<i>β</i>, GSDMD, and GSDMD-N normalized to <i>β</i>-actin. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2 

Figure 5 | Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2 