lncRNA MSTRG.29039.1 Promotes Proliferation by Sponging hsa-miR-12119 via JAK2/STAT3 Pathway in Multiple Myeloma

Figure 7

Knockdown of hsa-miR-12119 promotes MM cell proliferation. (a) The expression of OSMR after knocking down MSTRG and MSTRG+hsa-miR-12119 in AMO-1 and U266 cell lines by PCR. (b)The expression of hsa-miR-12119 after knocking down MSTRG and MSTRG+hsa-miR-12119 in AMO-1 and U266 cell lines by PCR. (c) The expression of OSMR/JAK2/STAT3/pJAK2/pSTAT3/GAPDH after knocking down MSTRG and MSTRG+hsa-miR-12119 in AMO-1 and U266 cell lines by Western blot. (d). Flow cytometric and statistical graphs of apoptosis after knocking down MSTRG and MSTRG+hsa-miR-12119 in U266 cell line. (e) Cell survival rate after knocking down MSTRG and si-MSTRG+ miRNA-inhibitor in U266 cell line. (f) Flow cytometric and statistical graphs of apoptosis after knocking down MSTRG and MSTRG+hsa-miR-12119 in AMO-1 cell line. (g) Cell survival rate after knocking down MSTRG and si-MSTRG+ miRNA-inhibitor in AMO-1 cell line (, , ).

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