Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD

Figure 2

The western diet triggers time-dependent changes in the hepatic mitochondrial lipidome. (a) Venn diagram of the 719 lipid species detected in the mitochondria-enriched fraction and the nonmitochondrial fraction. The analyses were pooled for all animals included in the study. The individual species are grouped within 16 lipid families. (b) Partial least square regression analysis of lipids in the liver. Left panels: from the mitochondria-enriched fractions in positive mode (505 lipid species, top panel) and negative mode (53 lipid species, bottom panel). Right panels: from the non-mitochondria fractions in positive mode (356 lipid species, top panel) and negative mode (59 lipid species, bottom panel).

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