Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD

Figure 5

Western diet increases semiquinone and ubiquinone levels in mitochondria. (a) Semiquinone from EPR spectrometry applied to a piece of the liver. (b) LC-MS ubiquinone semiquantification analysis was performed on the lipids extracted from the mitochondria-enriched fraction of the liver. Peak area values are arbitrary. (a, b) Data are expressed as ; 2-way ANOVA on rank with Tukey post hoc test; , , and versus control diet; ^$$ and ^$$$ versus weeks of diet. mice per time point per condition.

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