Inositol Alleviates Pulmonary Fibrosis by Promoting Autophagy via Inhibiting the HIF-1α-SLUG Axis in Acute Respiratory Distress Syndrome

Figure 3

SLUG was affected by inositol and contributed to the development of ARDS. (a, b) Volcano map of genes that were differentially expressed in the model group vs. the blank control group. (c, d) Heatmap of genes that were differentially expressed in the model group vs. the blank control group and in the model + inositol group vs. the model group; axis indicates the samples used for sequencing, and the axis indicates clusters of genes with similar expression patterns; green and red indicate the expression level from low to high. (e) The number of different genes expressed in the model group vs. the normal group, the model group vs. the inositol group, and the model + inositol group vs. the model group. (f) The Venn diagram shows the search for common genes that were differentially expressed in the model group vs. the normal group, the model group vs. the inositol group, and the model + inositol group vs. the model group. (g) The levels of SLUG, C4BPB, CALB1, N4BP3, and ALP1 expression were detected by qPCR; GAPDH served as a control. Data represent the mean , , Model vs. Blank: ; ^#, Model with Inositol vs. Model: ^##, ^###.

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