Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice

Figure 2

Diabetes-aggravated septic renal injury in mice. Renal pathology was clearly observed via renal H&E ((a) 200x) and periodic acid-Schiff (PAS) staining ((b) 200x). BODIPY staining ((c) 200x) was used to analyze the phospholipid accumulation in the proximal tubular cells of different groups of mice. The pathological score (d) was evaluated according to renal H&E staining. Serum urea nitrogen (BUN) (e), creatinine (CCr) (f), and cystatin C (Cysc) (g) levels, which reflect renal function, were determined. Furthermore, the survival rate (h) of diabetic mice subjected to LPS was calculated. Each bar represents the (). and , one-way ANOVA with Tukey’s test.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)