Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice

<div>Diabetes-exacerbated oxidative stress during septic renal injury. Renal reactive oxygen species (ROS) levels were detected by immunofluorescence (a). Renal 4-hydroxynonenal (4-HNE) immunohistochemical staining (b) and 8-hydroxydeoxyguanosine (8-OHdG) immunohistochemical staining (c) were performed to evaluate oxidative stress levels in the kidneys. Semiquantitative analysis of ROS immunofluorescence staining (d), 4-HNE immunohistochemical staining (e), and 8-OHdG immunohistochemical staining (f). 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice 