Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice

<div>Inhibition of the NADPH oxidase pathway attenuated renal ferroptosis accumulation. Ferroptosis-related proteins, including ASCL4, FTH1, and GPX4, were determined by western blotting (a). GPX4 levels were also detected by immunohistochemical staining (b). The renal scavenging effect on ROS is reflected by the glutathione reductase (GR) level (c). Morphological features of mitochondria were measured using electron microscopy (d). 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Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: Inhibition of the NADPH Oxidase Pathway Reduces Ferroptosis during Septic Renal Injury in Diabetic Mice 