lncRNA PINK1-AS Aggravates Cerebral Ischemia/Reperfusion Oxidative Stress Injury through Regulating ATF2 by Sponging miR-203

Figure 7

Sketch map of CI/R injury induced by lncRNA PINK1-AS. The expression of lncRNA PINK1-AS increased in brain tissues that have undergone CI/R injury. Highly expressed lncRNA PINK1-AS contributed to a low expression of miR-203 by acting as a sponge of miR-203. Low expression of miR-203 led to ATF2 expression upregulation. As a transcript factor of NOX2, highly expressed ATF2 contributed to high expression of NCF2 and NOX2, which led to ROS generation. Excessive ROS resulted in neuron cell apoptosis.