Characterization of Acetylation of Histone H3 at Lysine 9 in the Trigeminal Ganglion of a Rat Trigeminal Neuralgia Model

Figure 2

Overview of H3K9ac enrichment in the TN rat model. (a) Global H3K9ac staining in the trigeminal ganglion of the control, TN rat model, and TN rat model administered CBZ treatment (×200 magnification). The p-values were given by the comparison of H3K9ac positive puncta occupied in all cells between control and TN, as well as TN and CBZ. (b) Overall calling peaks of H3K9ac in the rat genome of control rats, TN rat model, and TN rat model administered CBZ treatment, by ChIP-seq. The values were given by the comparison of genomic H3K9ac peak counts between control and TN, as well as TN and CBZ. (c) Metagene profiles of genome-wide H3K9ac in the control, TN rat model, and TN rat model administered CBZ treatment. (d) The distribution of differentially H3K9ac-enriched regions in the genomic contexts of the control, TN rat model, and TN rat model administered CBZ treatment. (e) Diagram showing the intersection of genes with differential H3K9ac enrichment in the control, TN rat model, and TN rat model administered CBZ treatment.

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