Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway

Figure 3

DHA improved MI-induced cardiac dysfunction and inhibited cardiac apoptosis. (a and b) TTC staining was performed to assess the infarct area of MI mice and calculate the infarct area size ratio (; scale bar 3 mm). Data are . vs. sham, ^## vs. MI, . (c–e) Cardiac function analysed by echocardiography. (f and g) Myocardial fibrosis assessed by Masson’s staining (original magnification ×200; scale bar 50 μm). Data are . vs. sham, ^### vs. MI, . (h) Apoptosis of NMCs by TUNEL staining (red; original magnification ×200; scale bar 50 μm). (i) Quantitative analyses of TUNEL-positive cells. Data are . vs. control, ^## vs. hypoxia, .

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