Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases

Figure 5

The regulatory effects of AM on vascular homeostasis. AM maintains vascular homeostasis by promoting NO and actin formation and inhibiting vascular permeability, inflammation, and oxidative stress via binding to its receptor complexes CRLR/RAMP2 or CRLR/RAMP3. Abbreviations: AM: adrenomedullin; CRLR: calcitonin receptor-like receptor; RAMP: receptor activity-modifying protein.