The Effect of the NF<i>κ</i>B-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

<div>The molecular mechanism by which USP9X-Cx43 regulates the development of OPLL. After being activated by ER stress, NF<i>κ</i>B p65 translocated to nuclei and bonded to the promoter region of USP9X to upregulate its transcription. Enhanced expression of USP9X deubiquitinated Cx43 to protect it from degradation and contributed to the development of OPLL.</div>

Oxidative Medicine and Cellular Longevity

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Figure 7

Figure 7: The Effect of the NF<i>κ</i>B-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine 

Figure 7 | The Effect of the NFκB-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine 