MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-κB Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice

Figure 2

MDL-800 promoted migration and tube formation ability of HUVECs and enhanced the wound healing ability of HUVECs and HDFs. (a) Representative transwell migration assay images of HUVECS treated with different concentrations of MDL-800 (0, 0.5, and 2.5 μm). . (b) Quantitative analysis of crystal violet stained HUVECs corresponding to transwell migration assay. per group. (c, d) Quantitative analysis of junction number and tot branching length per field corresponding to tube formation assay. per group. (e) Representative tube formation assay images of HUVECS treated with different concentration of MDL-800 (0, 0.5, and 2.5 μm). . (f, g) Representative images of scratch wound healing assay of HUVECs in vitro at 0 and 12 h posttreatment and its quantitative analysis. and per group. (h, i) Representative images of scratch wound healing assay of HDFs in vitro at 0 and 12 h posttreatment and its quantitative analysis. and per group ().

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