MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-κB Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice

Figure 4

The skin wound healing promoting effects of MDL-800 in vivo. (a) As the animal experimental schematics show, mice were anesthetized and the dorsal fur was shaved and then two full-thickness wounds were made with biopsy punch per mice. (b) Representative images of the mice skin wound healing in the control, 5 mg/kg, and 25 mg/kg groups. The rulers in the pictures are shown in millimeters. (c) Schematic illustration of the mice skin wound healing over 18 days in control, 5 mg/kg, and 25 mg/kg group. (d) Wound area percentage at different time points (days 0, 3, 6, 9, and 18) in groups mentioned above. per group ().

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