MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-κB Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice

Figure 8

MDL-800 inhibited the NF-KB pathway in cutaneous wound. (a) Immunohistochemistry staining images of IL-6 and TNF-α of the control, 5 mg/kg, and 25 mg/kg groups on day 9 postsurgery. (b, c) Quantification of relative density of IL-6 and TNF-α of the groups mentioned above on day 9 postsurgery. per group. (d, e) Mice treated with various concentrations of MDL-800 and subjected to Western blot to analyze the expression of P65, PP65, lκB, P-lκB, and GAPDH. per group. (f) Schematic diagram of Mdl-800-mediated regulation of anti-inflammation and angiogenesis by inhibiting NF-κB/P65 pathway to accelerate wound healing ().

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