Water Treadmill Training Ameliorates Neurite Outgrowth Inhibition Associated with NGR/RhoA/ROCK by Inhibiting Astrocyte Activation following Spinal Cord Injury

Figure 8

Proposed mechanism by which TT protects the neurons after SCI. After SCI, “Naive” astrocytes are activated, and “Reactive” astrocytes secrete inflammatory mediators to directly damage neurons. In addition, CSPGs will bind to NGR1, 3, activate downstream RhoA/ROCK signaling pathway to inhibit neurite outgrowth, which indirectly damage neurons. TT can effectively inhibit the activation of astrocytes to promote axonal outgrowth after SCI.