Calycosin Alleviates Doxorubicin-Induced Cardiotoxicity and Pyroptosis by Inhibiting NLRP3 Inflammasome Activation

Figure 5

CAL alleviated DOX-induced cardiac dysfunction and myocardial injury in mice. (a) Schematic diagram of the experimental design. (b) Representative images of echocardiography tracing of mice treated with DOX and CAL at 29 days. (c) Vacuolation of cytoplasm by HE staining and quantified (). (d) Representative HE staining of mice heart. The representative degenerative vacuoles were indicated with arrowhead. (e) Myofibril loss by HE staining and quantified (). (f) Representative Masson trichrome staining of mice heart. (g) Collagen contents (). Data were depicted as . , compared with the control group, ^#, ^##, ^### compared with the DOX group.

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