Mesangial Cell–Derived Exosomal miR-4455 Induces Podocyte Injury in IgA Nephropathy by Targeting ULK2

<div>Effect of mesangial cell exosomes or miR-4455 mimics combined with ULK2 overexpression plasmid transfection on autophagy in podocytes. (a) Effect of miR-4455 mimics combined with ULK2 overexpression plasmid transfection on LC3II/I ratio and p62 protein content in human podocytes revealed by western blotting. (b) Quantitative plot of (a). (c) Effect of MC-ExoC or MC-ExoI combined with ULK2 overexpression plasmid transfection on LC3II/I ratio and p62 protein content in human podocytes revealed by western blotting. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Mesangial Cell–Derived Exosomal miR-4455 Induces Podocyte Injury in IgA Nephropathy by Targeting ULK2 