Research Article

Single-Cell RNA-Sequencing Analyses Revealed Heterogeneity and Dynamic Changes of Metabolic Pathways in Astrocytes at the Acute Phase of Ischemic Stroke

Table 1

Genes for metabolic procedures.

Metabolic proceduresGenes

GlycolysisAldoa, Aldob, Aldoc, Eno1, Eno2, Eno3, Gapdh, Gapdhs, Gck, Gdp1, Gpi1, Hk1, Hk2, Hk3, Mch1, Pfkm, Pfkl, Pfkp, Pgam1, Pgam2, Pgk1, Pkm, Pkm2, Pklr, Tpit
Tricarboxylic acid cycleAco2, Cs, Dlst, Dld, Fh1, Idh3a, Idh3b, Idh3g, Idh2, Ogdh, Pcx, Sdha, Sdhb, Sdhc, Sdhd, Suclg1, Suclg2, Suclg3
Intracellular transition of metabolic from glycolysis to tricarboxylic acid cycleDlat, Got1, Got2, Mdh1, Mdh2, MPC1, MPC2, Pdha1, Pdha2, Pdhb, Pdhx, Pdk1, Pdk2, Pdk3, Pdk4, Ppm2c
Oxidative phosphorylationAtp5a1, Atp5b, Atp5c1, Atp5d, Atp5e, Atp5j, Atp5o, Atp5f1, Atp5g2, Atp5g3, Atp5h, Atp5k, Atp5j2, Atp5l, Atp5s, Atpif1, Cox4i1, Cox5a, Cox5b, Cox6a1, Cox6a2, Cox6b1, Cox6c, Cox7a1, Cox7a3, Ndufa1, Ndufa2, Ndufa3, Ndufa4, Ndufa5, Ndufa6, Ndufa7, Ndufb3, Ndufb5, Ndufb10, Ndufc2, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufv3, Sdha, Sdhb, Sdhc, Sdhd, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrh, Uqcrq, Uqcr10, Uqcr11
Lactate metabolismLdha, Ldhal6b, Ldhb, Ldhc, Slc16a1, Slc16a3, Slc16a4, Slc16a7
Pentose phosphate pathway (PPP)G6pdx, Pgls, Pdg, Rpe, Rpia, Taldo1, Tkt
Glycogen metabolismUgp2, Gyg, Gys1, Gys2, Gsk3a, Gsk3b, Gbe1, Pygl, Pygm, Pygb, Agl
Glucose transportSlc2a1, Slc2a2, Slc2a3, Slc2a4, Slc2a5, Slc2a6, Slc2a7, Slc2a8, Slc2a9, Slc2a10, Slc2a11, Slc2a12
Glutamic metabolismSlca1, Slc1a2, Slc1a3, Slc1a6, Slc1a7, Slc38a1, Glul, P2rx7, Grin1, Grin2a, Grin2b, Grin2c, Nsmf
Fatty acids β-oxidationAcadl, Acadm, Dcer1, Dci, Echs1, Gcdh, Hadh, Hadha, Hadhb
Fatty acids synthesisAcaa2, Acaca, Acacb, Acsl1, Acsl2, Acsl3, Acsl4, Acsl5, Acsl6, Acss2, Acly, Decr1, Ech1, Echdc1, Echdc2, Echdc3, Echs1, Fasn, Mecr, Pecr, Scd1
Triacylglyceride synthesisAgps, Agpat1, Agpat2, Agpat3, Agpat4, Agpat5, Ayr1, Dgat1, Dgat2, Gk2, Gnpat, Gyk, Gpam, Gpd1, Lpl, Lipe, Lipc, Lipf, Mogat1, Mogat2, Mogat3, Pnpla2, Ppap2a, Ppap2b, Ppap2c