Inhibition of the TLR/NF-κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease

Figure 1

Plumbagin improves behavioural disorders and suppresses the loss of DA neurons in PD mice induced by MPTP or MPTP/probenecid. (a) The open field and (b) rotarod tests were performed to detect motor deficits in each mice group with the vehicle, MPTP, plumbagin+MPTP, and plumbagin (). (c) The open field and (d) rotarod tests were applied to detect motor deficits in each mice group with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin (). (e) Immunofluorescence staining was performed to detect TH-positive neurons in the SNpc of each mice group with the vehicle, MPTP, plumbagin+MPTP, and plumbagin (). Scale  μm. (f) Quantitative data of TH-positive neurons in SNpc of each mice group with the vehicle, MPTP, plumbagin+MPTP, and plumbagin (). (g) Immunofluorescence staining was performed to detect TH-positive neurons in the SNpc of each mice group with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin (). Scale  μm. (h) Quantitative data of TH-positive neurons in SNpc of each mice group with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin (). Data is presented as the , , , and .

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