Research Article

Inhibition of the TLR/NF-κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease

Figure 4

Plumbagin improved autophagy in PD mice induced by MPTP or MPTP/probenecid. (a) Western blotting analysis of LC3, p62, and p-mTOR in mice treated with the vehicle, MPTP, plumbagin+MPTP, and plumbagin. (b) Quantitative data of the LC3-II/LC3-I, p62, and p-mTOR protein levels in mice treated with the vehicle, MPTP, plumbagin+MPTP, and plumbagin. (c) Western blotting analysis of LC3, p62, and p-mTOR in mice treated with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin. (d) Quantitative data of the LC3-II/LC3-I, p62, and p-mTOR protein levels in mice treated with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin. Data are presented as the (). , , and .
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