Inhibition of the TLR/NF-<i>κ</i>B Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease

<div>Plumbagin improved autophagy in PD mice induced by MPTP or MPTP/probenecid. (a) Western blotting analysis of LC3, p62, and p-mTOR in mice treated with the vehicle, MPTP, plumbagin+MPTP, and plumbagin. (b) Quantitative data of the LC3-II/LC3-I, p62, and p-mTOR protein levels in mice treated with the vehicle, MPTP, plumbagin+MPTP, and plumbagin. (c) Western blotting analysis of LC3, p62, and p-mTOR in mice treated with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin. (d) Quantitative data of the LC3-II/LC3-I, p62, and p-mTOR protein levels in mice treated with the vehicle, MPTP/p, plumbagin+MPTP/p, and plumbagin. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Inhibition of the TLR/NF-<i>κ</i>B Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease 

Figure 4 | Inhibition of the TLR/NF-κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease 